Others
Categories
Featured Products
11beta,17,21-trihydroxypregn-4-ene-3,20-dione 21-methanesulphonate
- Chemical Name: 11beta,17,21-trihydroxypregn-4-ene-3,20-dione 21-methanesulphonate
- CAS: 6677-96-9
- Purity: 99%
Manufacturer Supply Best Quality 11beta,17,21-trihydroxypregn-4-ene-3,20-dione 21-methanesulphonate 6677-96-9 with Efficient Transportation
- Molecular Formula:C22H32 O7 S
- Molecular Weight:440.558
- PSA：126.35000
- LogP:2.84630
6677-96-9 Relevant articles
Steroidal C-21 mercapto derivatives as dissociated steroids: Discovery of an inhaled dissociated steroid
Biju, Purakkattle,McCormick, Kevin,Aslanian, Robert,Berlin, Michael,Solomon, Daniel,Chapman, Richard,McLeod, Robbie,Prelusky, Daniel,Eckel, Stephen,Kelly, George,Natiello, Michelle,House, Aileen,Fernandez, Xiomara,Bitar, Rema,Phillips, Jonathan,Anthes, John
scheme or table, p. 6343 - 6347 (2011/12/02)
A series of C-21 mercapto derivatives of...
C20-C21 SUBSTITUTED GLUCOCORTICOID RECEPTOR AGONISTS
-
Page/Page column 142, (2009/08/14)
-
C-21 THIOETHERS AS GLUCOCORTICOID RECEPTOR AGONISTS
-
Page/Page column 43, (2009/08/14)
The present invention provides compounds...
Synthesis of new local anti-inflammatory thiosteroids based on antedrug concept
Milioni, C,Jung, L,Koch, B
, p. 947 - 951 (2007/10/02)
The synthesis and the in vitro pharmacol...
6677-96-9 Process route
-
-
50-23-7
HYDROCORTISONE
-
-
124-63-0
methanesulfonyl chloride
-
-
6677-96-9
11β,7α-dihydroxy-21-<(methylsulfonyl)oxy>pregn-4-ene-3,20-dione
| Conditions | Yield |
|---|---|
|
With
pyridine;
at 0 ℃;
for 0.25h;
|
94% |
|
With
N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 0 - 20 ℃;
|
92% |
|
HYDROCORTISONE;
With
N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 0 ℃;
for 0.0833333h;
methanesulfonyl chloride;
In
dichloromethane;
at 0 ℃;
for 4 - 6h;
|
82% |
|
HYDROCORTISONE;
With
N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 0 ℃;
for 0.0833333h;
methanesulfonyl chloride;
In
dichloromethane;
at 0 ℃;
for 4 - 6h;
|
82% |
|
|
|
|
With
pyridine;
|
|
|
With
pyridine;
at 0 ℃;
for 1.5h;
|
-
-
6677-96-9
Hydrocortisone 21-methanesulfonate
| Conditions | Yield |
|---|---|
|
Hydrocortisone, Methanesulfonylchloride, Pyridin;
|
6677-96-9 Upstream products
-
50-23-7
HYDROCORTISONE
-
124-63-0
methanesulfonyl chloride
6677-96-9 Downstream products
-
434-02-6
21-fluoro-11β,17-dihydroxy-pregn-4-ene-3,20-dione
-
641-77-0
21-deoxycortisol
-
77826-00-7
(8S,9S,10R,11S,13S,14S,17R)-11-hydroxy-10,13-dimethyl-1,6,7,8,9,10,11,12,13,14,15,16-dodecahydrospiro[cyclopenta[a]phenanthrene-17,2′-oxetane]-3,3′(2H)-dione
-
114967-88-3
β-(11β,17α-Dihydroxy-4-pregnene-3,20-dion-21-yl-21-thio)propionic acid
